In 1993, Mr. Clark was appointed Vice President, Procurement and Materials Management. He became Vice President of North American Operations for the Merck Manufacturing Division in 1994 and Senior Vice President in 1996. In 1997, he was appointed Senior Vice President of Quality and Commercial Affairs. Later that year, Mr. Clark joined the Merck-Medco Managed Care subsidiary as Executive Vice President and Chief Operating Officer. He later served as Chairman, President and Chief Executive Officer of the newly named Medco Health Solutions, overseeing plans to prepare that organization to become a publicly traded company. He returned to the Merck Manufacturing Division as President in June 2003.

From 2008 to 2009 he served as board chairman of the Pharmaceutical Research and Manufacturers of America (PhRMA), which represents the country's leading pharmaceutical research and biotechnology companies. Mr. Clark earned his bachelor’s degree in Liberal Arts from Washington & Jefferson College, and his M.B.A. from American University. He served as a Lieutenant in the U.S. Army from 1970 to 1972 before joining Merck.     

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His awards include the Doris Duke Distinguished Clinical Science Professorship, the Lucille P. Markey Scholarship, Leukemia and Lymphoma Society Translational Investigator Awards, CapCure Awards, and election into the American Society of Clinical Investigation, the American Association of Physicians, and the Interurban Club. He Co-Chairs the Medical Board of the Laurie Strauss Leukemia Foundation, is a Director of Progenics Pharmaceuticals, a public biotech company, and he sits on the advisory boards of cancer centers and charitable foundations.